Monday, April 11, 2011

Miracle Foundation Awards $100,000 To Dr. Michael Wigler For Breakthrough Cancer Research

Miracle Foundation Awards $100,000 To Dr. Michael Wigler For Breakthrough Cancer Research

The MIRACLE (Making In Roads Against CancerÂ’s Lasting Effects) Foundation, a nonprofit cancer organization, announced that it has awarded a $100,000 grant to Dr. Michael Wigler of Cold Spring Harbor Laboratory for his continued research for finding a cure for cancer. This is the third grant he has received from The Miracle Foundation.

New York (PRWEB) July 23, 2005

The MIRACLE (Making In Roads Against CancerÂ’s Lasting Effects) Foundation, a nonprofit cancer organization, announced that it has awarded a $100,000 grant to Dr. Michael Wigler of Cold Spring Harbor Laboratory for his continued research for finding a cure for cancer. This is the third grant he has received from The Miracle Foundation.

Wigler is an internationally known cancer researcher with a focus in both molecular biology and the technology of cancer research itself. “We are delighted to award Dr. Wigler another grant of $100,000 to pursue his revolutionary cancer research,” said Joe Castronovo, president of The Miracle Foundation. “Dr. Wigler and his research team strive to achieve the greatest goal of all…to cure cancer. We support his endeavors and are proud that these funds can be used to help make great discoveries.”

The Miracle Foundation grant will fund Dr. WiglerÂ’s discovery of a complex technique known as ROMA (Representational Oligonucleotide Microarray Analysis).

"My team and I are eternally grateful to The Miracle Foundation to allow us to conduct ‘out of the box’ research that is not funded through more traditional means,” said Dr. Wigler. “Their ongoing support has been instrumental in enabling my team to make such extraordinary progress in cancer research.”

Background on Dr. Wigler

Wigler has also developed new methods for gene transfer and genetic manipulation of animal cells. In 1981, using gene transfer methods, Wigler isolated the first cancer-causing oncogene from a human tumor. He went on to study and document the function of the ras oncogene. The discovery has strongly influences todayÂ’s international cancer research.

Wigler and colleague Nikolai Lisitsyn developed a powerful research tool known as Representational Difference Analysis (RDA) in 1993. This technique simplifies the search for differences between two sets of DNA by comparing samples of healthy and diseased cells (i. e. cancer) from the same person in order to identify genetic differences between the two. RDA is now used by scientists nationwide and has facilitated many discoveries in cancer and infectious disease research. Dr. Wigler and his colleagues have themselves used RDA to discover several “cancer” genes including the well-known tumor suppressing gene P-TEN and DBC2.

The P-TEN discovery was an important scientific breakthrough. Mutations of the P-TEN gene have so far been found in breast, brain and prostate cancers. However, unlike gene mutations that have a role in the development of hereditary forms of cancer, most P-TEN mutations are found in more common sporadic, non-hereditary cancers. This is vitally important because more than 80 percent of all cancers are the sporadic type. P-TEN appears to play a role in the process whereby a benign tumor becomes malignant. The discovery of this gene will have major implications for improving diagnosis and treatment of cancers.

In order to accelerate research and streamline the RDA technique, Dr. Wigler and colleagues have also developed a sophisticated research technique based on DNA Microarrays, or “DNA Chip” technology. This method enables researchers to survey large numbers of genes in a single experiment.

About Cold Spring Laboratory

Cold Spring Harbor Laboratory is a private, non-profit basic research and educational institution that was established in 1890. The Laurel Hollow campus is home to more than 330 scientists who conduct groundbreaking research in cancer, neurobiology, plant biology and bioinformatics. Cancer research has been a major focus at the laboratory for more than 30 years — approximately two-thirds of all research at Cold Spring Harbor Laboratory is focused on cancer.

About The MIRACLE Foundation

The Miracle Foundation is a nonprofit organization whose mission is to support individuals and groups who can relieve the discomfort and burdens of those afflicted with cancer and to reduce the cancer death toll through care, scientific research and education. All funds raised by the Foundation support the work of individuals and organizations committed to achieving these goals. The organization was founded in 1999 by Michael and Patti Tenaglia after Michael was diagnosed with esophageal cancer. For more information, please call The Miracle Foundation at 516-873-0150 or visit www. miraclefoundation. com

###